01469nas a2200277   4500000000100000008004100001260000900042653001200051653001500063653002700078653001100105653000900116653001200125653001600137653002500153653001400178100001800192700002000210700001400230700001500244245007700259300000900336490000700345520082500352022001401177       1984                            d  c198410aAnimals10aArmadillos10aDisease Models, Animal10aFemale10aFoot10aleprosy10aLymph Nodes10aMycobacterium leprae10aXenarthra1 aPrabhakaran K1 aKirchheimer W F1 aSANCHEZ R1 aHarris E B00aAn alternative route for infecting armadillos with Mycobacterium leprae.  a83-60 v393 a<p>A nine-banded armadillo was inoculated with Mycobacterium leprae in both hind footpads. The animals were usually inoculated intravenously, or intradermally in the abdominal skin. Profuse multiplication of the bacilli occurred at the injection sites after more than two years. Eventually bacteraemia developed, and large numbers of the organisms were found in skin biopsies and in lymph nodes. There was limited dissemination of the bacteria into the spleen and the liver, and peripheral nerve invasion by the bacilli was also detected. M. leprae remained viable in the liver tissue, kept frozen at -80 degrees C for three years. This experimental system would be useful in testing the effects of certain immunological and chemotherapeutic agents against M. leprae by injecting them directly at the infection site.</p>  a0026-2633