01296nas a2200265   4500000000100000008004100001260001300042653001000055653001100065653002100076653001200097653001600109653001600125653002400141100001400165700001400179700001400193700001300207700001700220245010000237300001000337490000700347520066200354022001401016       1984                            d  c1984 Jun10aAdult10aHumans10aImmunity, Innate10aleprosy10aMacrophages10aMiddle Aged10aMycobacterium bovis1 aStach J L1 aDelgado G1 aStrobel M1 aMillan J1 aLagrange P H00aPreliminary evidence of natural resistance to Mycobacterium bovis (BCG) in lepromatous leprosy.  a140-60 v523 a<p>An assay system has been developed based on radiometric quantification of 3H uracil incorporation into viable BCG in the absence or presence of blood monocytes in cultures from untreated lepromatous (LL) or tuberculoid (TT) leprosy patients. 3H Uracil incorporation into BCG was inhibited when the bacilli were cultivated in the presence of blood-derived macrophages in culture for four days, and that inhibition was always greater with macrophages harvested from LL patients compared to TT patients. The reasons for such an observed difference in humans are discussed according to our knowledge obtained in murine models of mycobacterial infections.</p>  a0148-916X