01718nas a2200301   4500000000100000008004100001260000900042653002400051653002700075653001100102653001700113653001100130653002300141653001200164653001600176653003700192653002500229653001300254653001700267653001400284653001000298100002000308245003900328300001100367490000700378520101700385022001401402       1983                            d  c198310aAntigens, Bacterial10aDisease Susceptibility10aFemale10aHLA Antigens10aHumans10aImmunity, Cellular10aleprosy10aMacrophages10aMajor Histocompatibility Complex10aMycobacterium leprae10aPedigree10aPhagocytosis10aPregnancy10aTwins1 aSerjeantson S W00aHLA and susceptibility to leprosy.  a89-1120 v703 a<p>This review examines the evidence for involvement of MHC-associated factors in host immune response to Mycobacterium leprae, by collating HLA studies of sporadic and familial leprosy and discussing possible HLA-related immunological mechanisms in determining host response. Formal linkage analysis of 109 multiple-case families with data available for HLA haplotype segregation showed that under a three-allele recessive model for susceptibility to leprosy, linkage was observed between the HLA complex and a leprosy susceptibility locus at a recombination fraction of 20%. The significance of the linkage relationship was confined to families with at least two tuberculoid leprosy offspring and neither parent affected. When one parent was affected, with leprosy of any clinical type, lod scores could neither implicate nor exclude linkage between HLA and leprosy susceptibility and this apparent paradox can be explained by the presence of an additional, non-HLA linked susceptibility locus for leprosy.</p>  a0105-2896