01375nas a2200337   4500000000100000008004100001260001300042653001000055653001200065653002000077653001200097653001100109653001100120653002400131653001200155653001600167653000900183653000900192653002500201653001400226100001300240700001400253700001700267700001100284245014900295856007800444300001000522490000700532520048400539022001401023       1983                            d  c1983 Apr10aAdult10aAnimals10aCells, Cultured10aDapsone10aFemale10aHumans10aIn Vitro Techniques10aleprosy10aMacrophages10aMale10aMice10aMycobacterium leprae10aThymidine1 aMittal A1 aSathish M1 aSeshadri P S1 aNath I00aRapid, radiolabeled-microculture method that uses macrophages for in vitro evaluation of Mycobacterium leprae viability and drug susceptibility.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC272723/pdf/jcm00141-0158.pdf  a704-70 v173 a<p>This paper describes a microculture rapid assay using radiolabeling and mouse macrophages to determine the viability and the drug susceptibility or resistance of Mycobacterium leprae. Comparison of M. leprae resident macrophage cultures maintained in 96-well flat-bottomed plates showed results for viability and susceptibility or resistance to dapsone that were similar to results for concurrent cultures in Leighton tubes with greater numbers of bacilli and macrophages.</p>  a0095-1137