01409nas a2200277   4500000000100000008004100001260001300042653001200055653001200067653003100079653001100110653001000121653001200131653000900143653002500152100001500177700001700192700001900209700001600228245012900244300001100373490000700384050003200391520069400423022001401117       1983                            d  c1983 Apr10aAnimals10aDapsone10aDrug Resistance, Microbial10aHumans10aIndia10aleprosy10aMice10aMycobacterium leprae1 aNeelan P N1 aNoordeen S K1 aBalakrishnan S1 aPandian P R00aPrevalence survey of secondary dapsone resistance in leprosy in Kancheepuram and Tiruvannamalai control units of Tamil Nadu.  a222-300 v55  aInfolep Library - available3 a<p>A field survey was designed and carried out in parts of Kancheepuram and Tiruvannamalai Leprosy Control Units in Tamilnadu (population 418,000) with the objective of finding out the prevalence of secondary dapsone resistance among 790 lepromatous (LL and BL) cases, who formed the patient population at risk based on certain treatment criteria. Using the mouse footpad experiment, 3 resistant cases were identified in Kancheepuram Unit (prevalence rate of 1.0 per cent) and 11 cases in Tiruvannamalai Unit (prevalence rate of 2.2 per cent). The metabolic status of dapsone was found to be normal in more than 90% of the patients, showing no relationship to occurrence of resistance.</p>  a0024-1024