01544nas a2200313   4500000000100000008004100001260001300042653001200055653001700067653000900084653002800093653002700121653001400148653001100162653002900173653003100202653000900233653002000242653003000262100001700292700001800309245008700327856005800414300001100472490000700483050001700490520070900507022001401216       1983                            d  c1983 Jul10aAnimals10aCat Diseases10aCats10aDiagnosis, Differential10aDisease Models, Animal10aGranuloma10aHumans10aMycobacterium Infections10aMycobacterium lepraemurium10aRats10aRodent Diseases10aSkin Diseases, Infectious1 aSchiefer H B1 aMiddleton D M00aExperimental transmission of a feline mycobacterial skin disease (feline leprosy).  uhttp://vet.sagepub.com/content/20/4/460.full.pdf+html  a460-710 v20  aSCHIEFER19833 a<p>Non-culturable acid-fast bacteria from two spontaneous cases of so-called feline leprosy were transmitted to rats and cats and further passaged in rats or cats. Two to six months after infection, cats developed cutaneous lesions that were indistinguishable from spontaneous cases, including the occurrence of nasal granulomata in one cat. When injected into rats, the mycobacteria caused a generalized mycobacteriosis and the granulomatous reaction was composed chiefly of macrophages without polymorphonuclear granulocytes. Infection of cats with Mycobacterium lepraemurium did not produce any lesions. The feline disease may be a suitable model for the study of human leprosy (Hansen's Disease).</p>  a0300-9858