01307nas a2200313   4500000000100000008004100001260001300042653001200055653001600067653001400083653001800097653001200115653001000127653000900137653001500146653002500161653002500186653001700211653001300228100001200241700001200253700001700265700001300282245013700295300001200432490000700444520052800451022001400979       1983                            d  c1983 Sep10aAnimals10aEndothelium10aGranuloma10aKupffer Cells10aleprosy10aLiver10aMice10aMice, Nude10aMicroscopy, Electron10aMycobacterium leprae10aPhagocytosis10aVacuoles1 aJob C K1 aChehl S1 aHastings R C1 aRuby J R00aInvasion of liver parenchymal cells by Mycobacterium leprae in an experimentally infected nude mouse. An electron microscopic study.  a1088-950 v323 a<p>Liver tissue from a nude mouse infected with Mycobacterium leprae for 18 months was examined using light and electron microscopes. Numerous microgranulomas composed of macrophages were present throughout the liver. M. leprae in large numbers were present in Kupffer cells, macrophages, endothelial cells, and liver parenchymal cells. The study shows that the lower temperature of about 31 degrees C optimal for the growth of M. leprae is relative rather than absolute, and that M. leprae can invade even liver cells.</p>  a0002-9637