01470nas a2200313   4500000000100000008004100001260000900042653001000051653000900061653001500070653002800085653002900113653001800142653001900160653001200179653001100191653001200202653002600214653001600240100001500256700001300271700001200284700001600296245009300312300001000405490000800415520071900423022001401142       1984                            d  c198410aAdult10aAged10aAntibodies10aAntibodies, Antinuclear10aAntigen-Antibody Complex10aB-Lymphocytes10aDinitrophenols10aHaptens10aHumans10aleprosy10aLymphocyte Activation10aMiddle Aged1 aFurukawa F1 aOhshio G1 aOzaki M1 aHamashima Y00aAnti-hapten antibodies and autoantibodies in Japanese patients with lepromatous leprosy.  a195-80 v2763 a<p>In the sera of patients with lepromatous leprosy anti-DNP antibodies were detected in order to determine the mode of polyclonal B-cell activation. Anti-DNP antibodies were found in 30% of the patients with active lepromatous leprosy and in 8% of those with inactive lepromatous leprosy. The level of anti-DNP antibodies in active patients was significantly higher than the level in inactive patients and control. However, the presence of anti-DNP antibodies was unrelated to the production of circulating immune complexes and antinuclear antibodies. These results suggest that polyclonal B-cell activation might occur but that the B-cell clones stimulated by M. leprae are different from patient to patient.</p>  a0340-3696