01200nas a2200301   4500000000100000008004100001260001600042653001500058653001000073653001200083653003700095653001100132653001100143653003000154653001200184653000900196653001600205653001300221653002400234100001800258700001600276700001300292245007200305300001100377490000600388520049000394022001400884       1976                            d  c1976 Nov 2710aAdolescent10aAdult10aDapsone10aDose-Response Relationship, Drug10aFemale10aHumans10aHypersensitivity, Delayed10aleprosy10aMale10aMiddle Aged10aNeuritis10aProspective Studies1 aBarnetson R S1 aPearson J M1 aRees R J00aEvidence for prevention of borderline leprosy reactions by dapsone.  a1171-20 v23 a<p>68 patients were included in a prospective study of the treatment of borderline leprosy. 34 were treated with dapsone 5 mg daily, and 34 with 50 mg daily. Reversal reactions developed in 11 of those on 5 mg daily and in 3 of those on 50 mg daily. The statistically significant difference between the two treatment groups indicates that, contrary to previous teaching, dapsone given in higher dosage does not predispose patients to reversal reactions and indeed may prevent them.</p>  a0140-6736