01403nas a2200301   4500000000100000008004100001260000900042653001000051653001300061653000900074653001100083653002800094653001200122653000900134653001100143100001300154700001500167700001500182700001300197700001400210700001300224700001200237245002300249300000900272490000700281520079900288022001401087       1982                            d  c198210aAdult10aAlopecia10aFoot10aHumans10aImmune Complex Diseases10aleprosy10aMale10aTestis1 aGibert E1 aCubria J L1 aGratacos R1 aCastro J1 aMonfort J1 aCastel T1 aLecha M00a[Lucio's leprosy].  a41-60 v103 a<p>A case of diffuse lepromatous leprosy with lepra reaction type II-Lucio's phenomenon-in a 24 years old male patient is reported. The histological examination of the necrotic lesions and of the apparently normal skin showed the presence of dense perivascular and perianexial lymphohystiocitic infiltrates with great quantities of bacilli. The first biopsy did not show a picture a leuccocytoclastic vasculitis but only areas of necrosis. The immunofluorescence studies revealed on direct examination complement deposits on vessel walls. The complement levels in blood were lowered and circulating inmunecomplexes were also detected. These data confirm the opinion that Lucio's phenomenon is caused by circulating inmunecomplexes fixed on dermal vessel walls causing skin necrotic lesions.</p>  a0210-5187