01269nas a2200241   4500000000100000008004100001260001300042653001500055653001200070653001600082653001100098653001200109653000900121100001900130700001600149700001100165245005400176300001000230490000700240050003200247520073400279022001401013       1976                            d  c1976 Oct10aAdolescent10aAutopsy10aClofazimine10aHumans10aleprosy10aSkin1 aBalakrishnan S1 aDesikan K V1 aRamu G00aQuantitative estimation of clofazimine in tissue.  a732-80 v48  aInfolep Library - available3 a<p>The histological examination and the chemical estimation of clofazimine in the organs removed at autopsy of a patient receiving the drug indicated the accumulation of the drug in the organs of the reticulo-endothelial system and those having a large number of macrophages. The clofazimine levels in the skin from patients receiving the drug and those in whom the drug had been stopped for different periods of time were compared. The skin levels of clofazimine bore a direct relationship to the size of the granuloma. A slow elimination of the drug from the tissues was indicated by the presence of traces of the skin tissue even 1-2 years after stopping the drug. The clinical implication of these findings are discussed.</p>  a0024-1024