01502nas a2200265   4500000000100000008004100001260001600042653001500058653001000073653002100083653001100104653001200115653000900127653002300136653003900159653001600198100001500214700001900229700001400248245013400262300001200396490000700408520080700415022001401222       1982                            d  c1982 Apr 0810aAdolescent10aAdult10aElectromyography10aHumans10aleprosy10aMale10aNerve Regeneration10aPeripheral Nervous System Diseases10aPyrimidines1 aSébille A1 aSaint-André P1 aHugelin A00a[Acceleration by isaxonine of muscle reinnervation. Electrophysiological demonstration in leprotic neuropathy (author's transl)].  a1278-800 v113 a<p>On a model of compressive human neuropathy--leprous neuropathy occuring below an osteoligamentary canal following a process of sclerosis--a double-blind survey of isaxonine versus a placebo was undertaken after matching of patients to obtain similar pairs. After four months of treatment with isaxonine, the electrophysiological tests (EMG of the anterior tibialis and of the abductor digiti minimi muscle) showed a very significant improvement in the graphs of patients receiving the active agent, as compared to a lack of improvement, even an aggravation for those patients receiving the placebo. It may thus be concluded that muscular reinnervation has occurred, either by sprouting of the remaining healthy fibers or by regeneration of the damaged axons, or by both phenomena simultaneously.</p>  a0301-1518