01661nas a2200253   4500000000100000008004100001260001300042653002700055653002100082653001100103653001200114653001800126653003000144100001500174700001700189700001300206700001300219245011000232856004100342300001000383490000700393520099300400022001401393       1982                            d  c1982 Sep10aAntibodies, Monoclonal10aErythema Nodosum10aHumans10aleprosy10aT-Lymphocytes10aT-Lymphocytes, Regulatory1 aMshana R N1 aHaregewoin A1 aHarboe M1 aBelehu A00aThymus dependent lymphocytes in leprosy. I. T lymphocyte subpopulations defined by monoclonal antibodies.  uhttp://ila.ilsl.br/pdfs/v50n3a03.pdf  a291-60 v503 a<p>Monoclonal antibodies recognizing different human T lymphocyte subpopulations were used to characterize peripheral blood T lymphocytes in patients with leprosy. An increase in the suppressor T lymphocyte subpopulation was seen only in lepromatous leprosy (BL-LL) patients. In contrast, patients who had erythema nodosum leprosum (ENL) showed a disturbance in immunoregulation seen as a decrease of the suppressor cell percentage and manifested by an increase in in vitro lymphoproliferative responses to both PPD and PHA. This imbalance was seen to normalize as patients improved clinically. There was no deviation from the normal values of the total T lymphocyte population. It is suggested, therefore, that ENL may be associated with an acute imbalance of T lymphocyte subpopulations. Since the suppressor T lymphocyte identified by the mononuclear antibody used is antigen nonspecific, the significance of these suppressor cells in the pathogenesis of leprosy remains unclear.</p>
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