02095nas a2200409   4500000000100000008004100001260001600042653002700058653003500085653004100120653002000161653001100181653001200192653001600204653002500220653001400245653000900259653001800268653003400286653003000320100002000350700001300370700001400383700001600397700001700413700001400430700001500444700001300459700001600472700001500488700001300503245010600516300001100622490000800633520103000641022001401671       1982                            d  c1982 Dec 2310aAntibodies, Monoclonal10aFluorescent Antibody Technique10aHistocompatibility Antigens Class II10aHLA-DR Antigens10aHumans10aleprosy10aMacrophages10aMycobacterium leprae10aPhenotype10aSkin10aT-Lymphocytes10aT-Lymphocytes, Helper-Inducer10aT-Lymphocytes, Regulatory1 aVan Voorhis W C1 aKaplan G1 aSarno E N1 aHorwitz M A1 aSteinman R M1 aLevis W R1 aNogueira N1 aHair L S1 aGattass C R1 aArrick B A1 aCohn Z A00aThe cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes.  a1593-70 v3073 a<p>We report on the characteristics of cells in the cutaneous lesions and blood of 21 patients with lepromatous, tuberculoid, and intermediate forms of leprosy. A large proportion of the infiltrates in lepromatous lesions consist of macrophages heavily parasitized with Mycobacterium leprae. The T cells in the lesions are devoid of OKT4/Leu 3a-positive ("helper") cells and consist almost exclusively of OKT8/Leu 2a-positive ("suppressor") populations. In contrast, the tuberculoid infiltrates contain well-organized epithelioid and giant-cell granulomas and only remnants of bacilli, and the predominant T cell is from the OKT4/Leu 3a-positive subset. In both tuberculoid and lepromatous infiltrates, T cells and macrophages expressed HLA-DR antigen. No marked alteration in the distribution of blood T-cell phenotypes was noted. We conclude that there is a marked difference between T-cell subsets in lepromatous and tuberculoid infiltrates, which may influence the microbicidal activity of macrophages in the lesions.</p>  a0028-4793