01649nas a2200337   4500000000100000008004100001260001300042653001500055653001000070653000900080653001000089653002100099653002200120653001100142653002300153653001100176653002000187653001200207653000900219653001600228100001600244700001500260700001500275700001400290245004900304300001100353490000700364050003200371520089400403022001401297       1983                            d  c1983 Apr10aAdolescent10aAdult10aAged10aChild10aChild, Preschool10aConnective Tissue10aFemale10aGlycosaminoglycans10aHumans10aHyaluronic Acid10aleprosy10aMale10aMiddle Aged1 aSakuntala R1 aPratap V K1 aSharma N K1 aDayal S S00aAcid mucopolysaccharides in leprosy lesions.  a252-600 v55  aInfolep Library - available3 a<p>Uniform accumulation of acid mucopolysaccharides in all types of leprosy lesions was seen, except late tuberculoid lesions which showed the accumulation only at the periphery. Absence of acid mucopolysaccharides was significant in well formed epithelioid granulomas and in giant cells of late tuberculoid cases. Generally a progressive decrease with advancing chronicity of the disease was noted. The dermal zone without any cellular infiltrate showed abundant acid mucopolysaccharides in comparison to those areas having inflammatory cell infiltrate in 70.83% of LL, 42.86% of BL, 33.3% of BB, 40.0% of BT, and 13.51% of TT cases. In Indeterminate cases the distribution was same to that of control cases. Testicular hyaluronidase digestion established that hyaluronic acid constituted the main bulk of acid mucopolysaccharides. The possible source of hyaluronic acid is discussed.</p>  a0024-1024