01468nas a2200253   4500000000100000008004100001260001300042653001200055653001200067653001600079653000900095653002300104653002200127653003900149100001500188700001300203700001400216245010100230300001100331490000700342050003200349520081900381022001401200       1983                            d  c1983 Apr10aAnimals10aleprosy10aMacrophages10aMice10aNerve Regeneration10aPeripheral nerves10aPeripheral Nervous System Diseases1 aPandya S S1 aNaik S S1 aGurnani S00aAn attempt to influence nerve degeneration and regeneration by using macrophage cell homogenate.  a237-410 v55  aInfolep Library - available3 a<p>The effect of the contents of activated macrophages on the degenerative/regenerative process in the mouse sciatic nerve was investigated as a possible model for leprosy. The whole cellular homogenate or saline was injected every week around physically impaired (to bypass the perineurial barrier) and normal nerves. Recovery of the nerve function was monitored clinically and electromyographically. After 14 weeks animals were sacrificed and nerves were processed for histology. The data obtained from 134 experimental and control nerves were rated and analysed statistically. The course of the nerve regeneration in the physically impaired nerve with and without homogenate was found to be similar. One of the reasons for this could be insufficient concentration of the homogenate in the endoneurial space.</p>  a0024-1024