01883nas a2200313   4500000000100000008004100001260001300042653002000055653001900075653001900094653003000113653002000143653001100163653002700174653001200201653001800213653002000231100001300251700001300264700001800277700001400295700001500309245006400324300001000388490000700398050003200405520111800437022001401555       1982                            d  c1982 Jan10aAlpha-Globulins10aBeta-Globulins10aBlood Proteins10aElectrophoresis, Agar Gel10aGamma-Globulins10aHumans10aHypergammaglobulinemia10aleprosy10aSerum Albumin10aSerum Globulins1 aBaji P S1 aKher J R1 aGaneriwal S K1 aReddy B V1 aBulakh P M00aElectrophoretic pattern of proteins in lepromatous leprosy.  a82-940 v54  aInfolep Library - available3 a<p>Serum total proteins and the various protein fractions were studied in fifty cases of lepromatous leprosy and in eleven cases of lepromatous leprosy with lepra reaction. The study revealed a significant increase in serum total proteins in both lepromatous leprosy and lepra reaction groups, when compared with normal healthy subjects. The percentage rise was found to be 14.5% and 22.95% for lepromatous leprosy and lepra reaction respectively. The globulin fraction showed a significant elevation, while albumin showed a decrease. Thus a reversal of A/G ratio was observed in both the disease groups. Alpha-1 and Alpha-2 globulins were found to be significantly increased in both the disease groups. Beta globulins did not reveal any significant alteration. It was interesting to note the presence of an additional globulin fraction in seventeen patients of lepromatous leprosy and two cases of lepra reaction. Gammaglobulin showed a significant rise in lepromatous leprosy (56.16%) and in lepra reaction (60.72%). The significance of the above findings are discussed in the light of available literature.</p>  a0024-1024