01195nas a2200301   4500000000100000008004100001260001300042653001500055653001000070653000900080653003000089653002100119653001100140653001200151653002600163653003500189653001600224653001800240100001400258700001400272700001300286700001300299245007400312300001100386490000700397520047500404022001400879       1982                            d  c1982 Jun10aAdolescent10aAdult10aAged10aCytotoxicity, Immunologic10aErythema Nodosum10aHumans10aleprosy10aLymphocyte Activation10aLymphocyte Culture Test, Mixed10aMiddle Aged10aT-Lymphocytes1 aStach J L1 aStrobel M1 aFumoux F1 aBach J F00aDefect in the generation of cytotoxic T cells in lepromatous leprosy.  a633-400 v483 a<p>Cytotoxic T cells are consistently produced in normal individuals after in vitro stimulation by a pool of mitomycin-treated normal lymphocytes. Patients suffering from lepromatous leprosy (LL), presenting with large amounts of Mycobacterium leprae and without a history of erythema nodosum leprosum (ENL) are unable to generate such cytotoxic T cells, while lepromatous patients with ENL which, in the present study were all deprived of M. leprae, react normally.</p>  a0009-9104