01214nas a2200265   4500000000100000008004100001260000900042653002600051653002700077653002500104653001300129653001100142653002700153653001200180653002500192100001200217700001500229700001100244700001300255245014700268300001100415490000700426520050100433022001400934       1983                            d  c198310aAntibodies, Bacterial10aAntibodies, Monoclonal10aBinding, Competitive10aEpitopes10aHumans10aImmunologic Techniques10aleprosy10aMycobacterium leprae1 aSinha S1 aSengupta U1 aRamu G1 aIvanyi J00aA serological test for leprosy based on competitive inhibition of monoclonal antibody binding to the MY2a determinant of Mycobacterium leprae.  a869-710 v773 a<p>A novel serological assay for leprosy has been devised on the basis of serum inhibition of binding of 125I-labelled ML04 monoclonal antibody to Mycobacterium leprae sonicate-coated microtitre plates. Antibodies were detected in 93% of lepromatous leprosy patients, whereas controls from the endemic area, including leprosy contacts and patients with tuberculosis, were serologically negative. The specificity and efficacy of the test may offer an advantage over previously used techniques.</p>  a0035-9203