02149nas a2200301   4500000000100000008004100001260001700042653001900059653003400078653003200112653001800144653001100162653001900173653001200192653001200204100001500216700001500231700001600246700001800262700001900280700001300299245006600312300001100378490000700389050003200396520140500428022001401833       1984                            d  c1984 Oct-Dec10aAdrenal Cortex10aAdrenal Cortex Function Tests10aAdrenocorticotropic Hormone10aBlood Glucose10aHumans10aHydrocortisone10aInsulin10aleprosy1 aDurairaj V1 aRadhabai K1 aAlagappan R1 aKoteeswaran A1 aVenkataraman V1 aKannan K00aAdrenal cortical function and reserve in lepromatous leprosy.  a828-340 v56  aInfolep Library - available3 a<p>22 chronic Lepromatous Leprosy patients of over 10 years duration, 17 non-reactional and 5 in reactional state who have not taken steroids as part of treatment were selected for the study. Serum cortisol was estimated by Radio-immuno-assay. Samples for basal values were collected at 8.00 A.M. Stimulated values were estimated in samples collected 8 hours after ACTH gel 40 units IM or 2 hours after 0.15 unit/kg BW Plain Insulin I.V. Basal cortisol values are: Normal controls 123.06 +/- 57.33 ng/ml. Non-reactional: 100.47 +/- 30.33 ng/ml; Reactional 141.4 +/- 43.15 ng/ml. Stimulated values are: Normal controls: 207.6 +/- 72.57 ng/ml. Non-reactional: 175.33 +/- 57.07 ng/ml, Reactional: 230 +/- 40.92 ng/ml. Basal serum cortisol in the non-reactional state is slightly lower than in normals but not statistically significant (P greater than 0.1). The basal cortisol in reactional subjects is slightly higher than in normals but not significant statistically (P greater than 0.05). The percentage rise over the basal value after stimulation test is found to be significantly low in both the reactional and non reactional states (P greater than 0.05) and also there is no statistically significant difference between these two groups (p greater than 0.5). Hence it is concluded that the Adrenal cortical reserve is low both in the non-reactional and reactional states of Lepromatous Leprosy.</p>  a0254-9395