01762nas a2200301   4500000000100000008004100001260001700042653002400059653001200083653004100095653000900136653001100145653002900156653001200185653001300197653001200210653000900222653001400231653001500245100002300260700001600283245003600299300001200335490000600347050001600353520107700369022001401446       1984                            d  c1984 Oct-Dec10a5-Hydroxytryptophan10aAnimals10aChromatography, High Pressure Liquid10aDiet10aHumans10aHydroxyindoleacetic Acid10aIndoles10aKinetics10aleprosy10aMice10aSerotonin10aTryptophan1 aMester de Parajd L1 aGarnier J P00aNutritional aspects of leprosy.  a293-3030 v2  aMESTER 19843 a<p>Desoxyfructo-serotonin (DFS) being a naturally occurring metabolite, which, like serotonin, has its origin in tryptophane in the food, one can ask about the role of nutrition in leprosy. The unique situation, that a human metabolite shows antileprosy activity, confirmed in vitro and in vivo, makes it possible to develop a "build in" antileprosy therapy. This is now realised through a so-called "Anti-Leprosy Nutriment" (NAL). The effectiveness of this diet was confirmed by the fact, that a daily dose of 0.5 g NAL per mouse has a similar effect, like 20 mg/kg body weight Dapsone per day in the conventionnal mouse foot-pad test. The biosynthesis of DFS in man has been demonstrated by high performance liquid chromatography (HPLC), spectrofluorometry and mass spectrometry. The activity of NAL (rich in tryptophane, unsaturated fatty acids and glucose) is due to an increased biosynthesis of DSF. The latter may be considered as a "physiological protecting agent" against leprosy. This type of food may play a role in the prevention of leprosy in endemic area.</p>  a0001-5938