01363nas a2200337   4500000000100000008004100001260001300042653001500055653002500070653001400095653001800109653002000127653001400147653001100161653001800172653001800190653001400208653001200222653002800234653003200262653000900294100001200303700001500315700001200330700001600342245010400358300001000462490000700472520053200479022001401011       1999                            d  c1999 May10aAntibodies10aAntibody Specificity10aApoptosis10aCD28 Antigens10aCells, Cultured10aCytokines10aHumans10aInterleukin-110aInterleukin-610aIonomycin10aleprosy10aLeukocytes, Mononuclear10aTumor Necrosis Factor-alpha10aZinc1 aGupta A1 aSharma V K1 aVohra H1 aGanguly N K00aSpontaneous apoptosis in peripheral blood mononuclear cells of leprosy patients: role of cytokines.  a49-550 v243 a<p>Peripheral blood mononuclear cells from leprosy patients underwent spontaneous apoptosis upon culture for 24 h. The apoptosis was inhibited by anti-TNFalpha antibodies and to a certain extent by anti-IL-1alpha and IL-6, thus showing that T(H)2-type cytokines (mainly TNFalpha) are responsible for inducing apoptosis. This cytokine-mediated apoptosis could be inhibited by ionomycin and zinc, thereby suggesting that these metal ions can be used to decrease the levels of these inflammatory cytokines in various diseases.</p>  a0928-8244