01518nas a2200277   4500000000100000008004100001260001700042653001900059653001100078653002100089653002100110653002000131653001200151100001400163700001400177700001300191700001400204700001200218700001700230700001400247245005100261300000900312490000700321520089800328022001401226       1978                            d  c1978 Jan-Mar10aBlood Proteins10aHumans10aImmunoglobulin A10aImmunoglobulin M10aImmunoglobulins10aleprosy1 aGupta S C1 aSinha S N1 aSharma D1 aBajaj A K1 aBisht D1 aMehrotra T N1 aGupta R M00aSerum proteins and immunoglobulins in leprosy.  a9-130 v463 a<p>Serum proteins and immunoglobulins were studied in patients suffering from various types of leprosy. A significant increase in total protein and decrease in albumin was found in all types of leprosy except borderline-tuberculoid. Gamma globulin was found to be increased in all types. An increase of alpha-2-globulin in lepromatous, a decrease of beta globulin in borderline-lepromatous, and a decrease of alpha-2 and increase of beta globulin in borderline-tuberculoid were observed. These changes do not seem to be of diagnostic importance. A statistically significant increase of IgG in borderline-lepromatous and lepromatous, IgM in all types of leprosy and IgA only in lepromatous was found. The increase of different immunoglobulins in leprosy, especially the lepromatous type, suggests a humoral response which was found to be directly proportional to the severity of the lesion.</p>  a0148-916X