01196nas a2200325 4500000000100000008004100001260000900042653000900051653002200060653001200082653001100094653001200105653003100117653001100148653002400159653000900183653000900192653002400201653002500225100001400250700001600264700002100280700001400301700001600315245011800331300001000449490000700459520039000466022001400856 1989 d c198910aAged10aAged, 80 and over10aAnimals10aBrazil10aDapsone10aDrug Resistance, Microbial10aHumans10aLeprosy, Borderline10aMale10aMice10aMice, Inbred BALB C10aMycobacterium leprae1 aGallo M E1 aDamasco M H1 aAlburquerque E C1 aSilva T C1 aAlmeida S M00a[Secondary sulfone resistance--presentation of a case of leprosy-Oswaldo Cruz Foundation, Rio de Janeiro-Brazil]. a103-40 v173 a
Report on a case of dapsone resistance in a BL patient with clinical diagnosis and laboratory confirmation. The resistance appeared after 17 years of dapsone treatment, and the laboratory tests revealed total resistance to all the tested dapsone concentrations. The case reported occurred in the city of Rio de Janeiro (Brazil) which presents a leprosy prevalence of 1.79/1,000.
a0210-5187