01382nas a2200301   4500000000100000008004100001260001300042653001200055653001300067653002200080653001200102653002400114653001400138653001100152653001200163653002500175653002500200653001300225653000900238653002600247653001700273100001600290245008300306300001100389490000700400520065900407022001401066       1975                            d  c1975 Aug10aAnimals10aCollagen10aConnective Tissue10aDapsone10aExtracellular Space10aGranuloma10aHumans10aleprosy10aMicroscopy, Electron10aMycobacterium leprae10aRifampin10aSkin10aStaining and Labeling10aStreptomycin1 aEdwards R P00aLong-spacing collagen in skin biopsies from patients with lepromatous leprosy.  a175-820 v933 a<p>In the course fo evaluating the effect of different drugs on the morphology of Mycobacterium leprae (Edwards, Draper & Draper, 1972) and on the phagocytic cells containing these organisms (Edwards, 1973), an unusual feature was observed in the dermal connective tissue of skin biopsies obtained from some of the patients. Variable amounts of an extracellular, cross-striated osmiophilic material were present in the dermis. The purpose of this communication is to describe the banded substance observed in the extracellular space of the lepromatous skin and to compare it briefly with similar substances and structures reported to occur elsewhere.</p>  a0007-0963