01751nas a2200289   4500000000100000008004100001260001600042653001600058653001900074653002100093653001100114653001200125653002000137653001700157653001600174653001500190100001500205700001500220700001400235700001600249700001400265245012200279300001000401490000600411520103000417022001401447       1975                            d  c1975 Sep 2710aAmyloidosis10aBlood Proteins10aErythema Nodosum10aHumans10aleprosy10aLeukocyte Count10aLeukocytosis10aNeutrophils10aRecurrence1 aMcAdam K P1 aAnders R F1 aSmith S R1 aRussell D A1 aPrice M A00aAssociation of amyloidosis with erythema nodosum leprosum reactions and recurrent neutrophil leucocytosis in leprosy.  a572-30 v23 a<p>Rectal biopsy in 190 inpatients at a leprosy hospital in the Highlands of Papua New Guinea disclosed 16 patients with secondary amyloidosis. This represented 20% of the patients who had had polar lepromatous leprosy (L.L.) for more than 2 years. Patients with amyloidosis characteristically had either a history of recurrent attacks of erythema nodosum leprosum (E.NH) reactions or chronic trophic ulcers. Levels of the serum component (protein SAA) antigenically related to the amyloid fibril protein AA were monitored, at varying intervals for three months, in lepromatous patients with E.N.L. reaction. The SAA levels rose during E.N.L. reactions in parallel with the neutrophil count. SAA occurred with greatest frequency among patients with LH, while most non-lepromatous patients with detectable SAA had chronic trophic ulcers. The correlation between raised neutrophil count and elevated SAA concentration, observed in this and other studies, suggests that neutrophils are associated with the production of SAA.</p>  a0140-6736