01417nas a2200241   4500000000100000008004100001260001300042653002400055653001100079653003000090653001300120653001200133100001200145700001500157700001100172700001600183245008300199300001000282490000700292050003200299520083000331022001401161       1979                            d  c1979 Jul10aAntigens, Bacterial10aHumans10aHypersensitivity, Delayed10aLepromin10aleprosy1 aSinha S1 aSengupta U1 aRamu G1 aDesikan K V00aAssessment of Dharmendra antigen. III. Comparative study with Mitsuda antigen.  a323-90 v51  aInfolep Library - available3 a<p>Four fractions each from Dharmendra and Mitsuda antigen have been obtained by step-wise centrifugation and sonication of the antigen. These fractions have been assessed for their capacity of inducing skin delayed hypersensitivity response. While, it has been noted that all fractions of both types of antigens can induce a good early reaction, the late skin reaction is only mounted by intact bacilli of both types of antigen. When compared at a constant bacillary concentration, Dharmendra antigen has produced better early skin reaction than Mitsuda antigen, whereas the intensity of late skin reaction is almost equal with both the antigens. The hypothesis has been put forward that the early, as well as the late reaction are produced by the same antigen and this antigen is located in the protoplasm of M. leprae.</p>  a0024-1024