01122nas a2200205   4500000000100000008004100001260001600042653003000058653002000088653001400108653001100122653001200133100001300145700001200158245007200170300001000242490000600252520064400258022001400902       1972                            d  c1972 Aug 1210aCholinesterase Inhibitors10aCholinesterases10aDibucaine10aHumans10aleprosy1 aThomas M1 aJob C K00aSerum atypical pseudocholinesterase and genetic factors in leprosy.  a390-10 v33 a<p>The levels of pseudocholinesterase and its nature were studied in 390 leprosy patients and 343 control subjects. The levels of the enzyme in both leprosy patients and normal controls were comparable. The study of the nature of the enzyme by determining its dibucaine number showed that a statistically significant number of lepromatous patients had the atypical variety of the enzyme compared with normal controls or tuberculoid patients. Since the presence of the atypical variety of the enzyme is genetically determined it is suggested that genetic factors play an important part in deciding susceptibility to lepromatous leprosy.</p>  a0007-1447