01211nas a2200229   4500000000100000008004100001260000900042653001100051653002200062653001100084653001200095653000900107653001600116653001300132653001600145100001400161245007000175300001100245490000700256520070400263022001400967       1979                            d  c197910aFemale10aGenetic Variation10aHumans10aleprosy10aMale10aMathematics10aPedigree10aPhilippines1 aSmith D G00aThe genetic hypothesis for susceptibility to lepromatous leprosy.  a163-770 v503 a<p>Evidence for genetic influence of the host response to infection with Mycobacterium leprae is reviewed. A complex segregation analysis is performed on data for 91 families from Mactan, Philippines, in each of which at least one offspring developed lepromatous leprosy. The data are not found to be inconsistent with an autosomal recessive hypothesis for susceptibility to lepromatous leprosy. Heritability estimates in the range of 80% were calculated for sib-sib pairs under the multifactorial hypothesis for susceptibility. It is argued that the multifactorial hypothesis is more in keeping with available immunologic, epidemiologic, and demographic data than is the single gene hypothesis.</p>  a0340-6717