01597nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653000900080653001000089653001800099653001800117653003100135653001100166653002100177653002000198653001200218653001600230653000900246100001800255700001200273700002700285700001200312245011300324300001000437490000700447520080300454022001401257       1979                            d  c1979 Sep10aAdolescent10aAdult10aAged10aChild10aComplement C310aComplement C410aComplement System Proteins10aHumans10aImmunoglobulin G10aImmunoglobulins10aleprosy10aMiddle Aged10aSkin1 aLai A Fat R F1 aJin J C1 aDiesselhoff-den Dulk M1 aFurth R00aIn vitro synthesis of humoral factors (immunoglobulins and complement) in lesional skin of leprosy patients.  a891-50 v253 a<p>An in vitro culture technique was used to demonstrate the synthesis of immunoglobulins and complement in lesional skin of patients representing the entire clinico-histopathological spectrum of leprosy. The results indicate that immunoglobulin G is produced in different amounts in the various forms of leprosy. Classification of the patients according to the three main groups shows that a small amount of immunoglobulin G synthesis occurred in tuberculoid leprosy, a distinct amount occurred in borderline leprosy, and large amount occurred in lepromatous leprosy. Contrary to expectation, synthesis of C3 was found only in some of the cultures of these three forms of leprosy. The function of the locally synthesized immunoglobulin G and the findings concerning C3 synthesis are discussed.</p>  a0019-9567