01606nas a2200325   4500000000100000008004100001260000900042653001200051653001600063653001600079653001200095653002700107653002000134653003300154653003100187653001100218653001200229653000900241653002500250653002200275653001300297653001500310100001600325245004600341856008300387300001000470490000700480520077900487022001401266       1971                            d  c197110aAnimals10aBCG Vaccine10aClofazimine10aDapsone10aDisease Models, Animal10aDrug Evaluation10aDrug Evaluation, Preclinical10aDrug Resistance, Microbial10aHumans10aleprosy10aMice10aMycobacterium leprae10aRadiation Effects10aRifampin10aThymectomy1 aShepard C C00aThe first decade in experimental leprosy.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427880/pdf/bullwho00203-0102.pdf  a821-70 v443 a<p>Considerable developments have occurred in the application of the method for growing Mycobacterium leprae in the mouse foot-pad since it was first described about 10 years ago. The method has been used to study growth curves and histology in normal and in thymectomized irradiated mice, to identify supposed isolates of Myco. leprae that have been made in tissue-culture or in non-living media, to evaluate tests of experimental vaccines, to investigate applications to clinical investigations (the loss of infectivity during chemotherapy as a means of monitoring a drug trial, the demonstration of drug-resistance, and the clinical problem of the patient who responds poorly to therapy), and to study new drugs-e.g., dapsone, acedapsone, clofazimine, and rifampicin.</p>  a0042-9686