01980nas a2200373   4500000000100000008004100001260000900042653001800051653001500069653001000084653001200094653002900106653001100135653001200146653000900158653001600167653001600183653003000199100001400229700002400243700001500267700001600282700001000298700001800308700002500326700001600351700001200367245014000379856008300519300001100602490000700613520097200620022001401592       1971                            d  c197110aAcute disease10aAdolescent10aAdult10aAspirin10aClinical Trials as Topic10aHumans10aleprosy10aMale10aMiddle Aged10aThalidomide10aWorld Health Organization1 aBechelli 1 aMartinez Dominguez 1 aRamanujam 1 aLanguillon 1 aIyer 1 aDe Las Aguas 1 aTARABINI-CASTELLANI 1 aSundaresan 1 aUemura 00aWHO co-ordinated short-term double-blind trial with thalidomide in the treatment of acute lepra reactions in male lepromatous patients.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2427977/pdf/bullwho00199-0029.pdf  a719-320 v453 a<p>The treatment of lepra reactions constitutes one of the most serious problems in leprosy. For this reason, the first reports in 1965 of the favourable results obtained with thalidomide aroused considerable interest and led WHO, in 1967, to carry out a trial with the co-operation of four centres. A short-term double-blind trial was designed to study the effect of thalidomide, in comparison with acetylsalicylic acid, in the treatment of acute lepra reactions in male lepromatous patients. Acetylsalicylic acid was used instead of a placebo because of its antipyretic and analgesic activity. Because of the severe adverse reactions that may be caused by thalidomide, mainly the teratogenic effects, only males were included in the trial.The results of this short-term study seem to confirm previous reports of the efficacy of thalidomide and indicate that acetylsalicylic acid also seems to be helpful in the management of certain symptoms of lepra reactions.</p>  a0042-9686