01110nas a2200277   4500000000100000008004100001260001600042653001200058653001100070653000900081653001400090653001200104653000900116653002300125653002500148653002300173100001300196700001600209700001300225700001600238245003400254300001000288490000600298520051400304022001400818       1969                            d  c1969 Jul 2610aAnimals10aFemale10aFoot10aGranuloma10aleprosy10aMice10aModels, Biological10aMycobacterium leprae10aNerve Degeneration1 aRees R J1 aWeddell A G1 aPALMER E1 aPearson J M00aHuman leprosy in normal mice.  a216-70 v33 a<p>It has now been shown that normal mice can be used as models for studying the early stages in the development of leprosy. Inoculation into the foot pads of mice of as few as 10(4) leprosy bacilli leads to infections which spread to distant sites via the blood stream and after two or more years give rise to granulomata and neural damage at the sites of inoculation. Where the tissue response had fully developed it reproduced exactly the histological features of human leprosy in the borderline range.</p>  a0007-1447