01961nas a2200481   4500000000100000008004100001260001300042653001500055653001000070653001600080653002600096653002400122653001000146653002100156653003800177653001100215653001600226653001100242653002100253653001000274653001100284653001200295653002500307653000900332653001600341653002500357653001500382653001600397100002000413700001200433700001400445700001800459700002100477700001300498700001500511700001200526245012800538856004100666300001100707490000700718520074000725022001401465       1991                            d  c1991 Sep10aAdolescent10aAdult10aAge Factors10aAntibodies, Bacterial10aAntigens, Bacterial10aChild10aChild, Preschool10aEnzyme-Linked Immunosorbent Assay10aFemale10aGlycolipids10aHumans10aImmunoglobulin M10aIndia10aInfant10aleprosy10aLongitudinal studies10aMale10aMiddle Aged10aMycobacterium leprae10aPrevalence10aSex Factors1 aKrishnamurthy P1 aRao P S1 aReddy B N1 aSubramanian M1 aDhandayudapani S1 aBhatia V1 aNeelan P N1 aDutta A00aSeroepidemiological study of leprosy in a highly endemic population of south India based on an ELISA using synthetic PGL-I.  uhttp://ila.ilsl.br/pdfs/v59n3a06.pdf  a426-310 v593 a<p>As part of a continuing longitudinal immuno-epidemiological study, blood samples were collected by finger prick from 4243 individuals living in a highly endemic area for leprosy in South India. The samples were tested for IgM antibodies against phenolic glycolipid-I using an ELISA. Seropositivity defined as optical density greater than or equal to 0.2000 was marginally higher in the age group 10-30 years and in females. There was no evidence for a higher level in contacts than in non-contacts. The future prospect for the large scale use of this ELISA in high-endemic populations in special epidemiological investigations or routine control programs as a serological tool to detect leprosy infection appears questionable.</p>
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