01655nas a2200337   4500000000100000008004100001260001300042653002200055653001200077653002300089653002000112653003100132653002300163653001200186653001600198653000900214653002500223653001800248653002100266653001400287653001200301653001300313653001800326100001100344700001600355245008700371300001000458490000800468520082700476022001401303       1975                            d  c1975 May10aAniline Compounds10aAnimals10aAntithyroid Agents10aDrug Evaluation10aDrug Resistance, Microbial10aLeprostatic Agents10aleprosy10aMethimazole10aMice10aMycobacterium leprae10aPhenyl Ethers10aPropylthiouracil10aThiazoles10aThiones10aThiourea10aThyroid (USP)1 aLevy L1 aUllmann N M00aInhibition of multiplication of Mycobacterium leprae by several antithyroid drugs.  a651-50 v1113 a<p>Multiplication of Mycobacterium leprae in the mouse footpad was inhibited when mice were fed, mixed in their diet, 0.05 per cent methimazole, 0.066 per cent USP thyroid powder, methimazole plus thyroid powder, 0.15 per cent 5-n-heptyl-2-thioxo-4-thiazolidinone, 0.1 per cent propylthiouracil, and 0.1 per cent thambutosine for 154 days, beginning on the day of inoculation. All of the treatment regimens, except for the 2 containing thyroid powder, decreased the plasma concentrations of thyroxine and protein-bound iodine. It is suggested that the 2 antithyroid drugs, methiomazole and propylthiouracil, and the 2 antimicrobial agents, heptylthioxothiazolidinone and thiambutosine, all of which possess structural features in common, may exert the antithyroid and antimicrobial effects through a common mechanisms.</p>  a0003-0805