01458nas a2200253   4500000000100000008004100001260001300042653001000055653001000065653001200075653001700087653003100104653003100135653001100166653001200177653002600189100001400215245006200229300001100291490000700302050003200309520084900341022001401190       1979                            d  c1979 Apr10aAdult10aChild10aDapsone10aEye diseases10aFoot Deformities, Acquired10aHand Deformities, Acquired10aHumans10aleprosy10aRetrospective Studies1 aGupte M D00aDapsone treatment and deformities. A retrospective study.  a218-350 v51  aInfolep Library - available3 a<p>Gandhi Memorial Leprosy Foundation conducted a study from 1963-72. Records of 2608 patients pertaining to type of leprosy, year of detection and registration, involvement of nerves, treatment, reactions, deformities, were available for a retrospective study. Patients having problems like neuritis and deformities and of the types lepromatous and borderline were the ones who tended to be regular clinic attenders. Lepromatous and Borderline and Polyneuritic types and N3 group were prone to develop deformities. There seemed to be association between reaction and causation of deformities. Because of the neurotoxic effect and ability to concentrate in the affected nerves, dapsone might enhance the risk of deformities. Low deformity rates in N1 and N2 types of nerve involvement reaffirmed the necessity of early diagnosis of leprosy.</p>  a0024-1024