01564nas a2200325   4500000000100000008004100001260001300042653002300055653001100078653001900089653001700108653001100125653001000136653001200146653000900158653001300167100001100180700001200191700001600203700001300219700001600232700001800248700001500266700001400281245006700295300001100362490000700373520084400380022001401224       1980                            d  c1980 May10aChromosome Mapping10aFemale10aGene Frequency10aHLA Antigens10aHumans10aIndia10aleprosy10aMale10aPedigree1 aWolf E1 aFine PE1 aPritchard J1 aWatson B1 aBradley D J1 aFestenstein H1 aChacko C J1 aStevens A00aHLA-A, B and C antigens in South Indian families with leprosy.  a436-460 v153 a<p>Seventy-two families, selected for having at least two children affected with leprosy, were HLA typed for 57 A, B and C locus antigens recognized by the WHO Nomenclature Committee. In addition, 20 possible new "splits" were investigated. The distribution of A, B and C locus antigens in affected and unaffected family members was similar, irrespective of the type of leprosy in the family. Gene frequencies (derived by direct gene counting from 253 haplotypes), haplotype frequencies and delta values were calculated. There is evidence for heterogeneity of B5, B15, B17, Bw16 and Bw35 and for the existence of at least one A locus and one B locus antigen not previously detected. The value of the HLA system for detecting expaternal children in a highly inbred population and the effect of inbreeding on the HLA system is discussed.</p>  a0001-2815