01467nas a2200325   4500000000100000008004100001260001300042653001100055653001900066653001700085653003100102653001100133653001000144653001200154653000900166653002900175653004500204653001400249100001100263700001400274700001500288700001400303700001800317700001300335245008400348300001100432490000700443520067700450022001401127       1981                            d  c1981 Sep10aFemale10aGene Frequency10aHLA Antigens10aHistocompatibility Testing10aHumans10aIndia10aleprosy10aMale10aMycobacterium Infections10aMycobacterium Infections, Nontuberculous10aPhenotype1 aEden W1 aMehra N K1 aVaidya M C1 aD'Amaro J1 aSchreuder G M1 aRood J J00aHLA and sporadic tuberculoid leprosy: a population study in Maharashtra, India.  a189-940 v183 a<p>A population study to test whether associations between HLA and sporadic--i.e. non-familial--tuberculoid leprosy exist was undertaken in a hyperendemic area in India. Since previous family studies in the same area had shown both non-random haplotype segregation in the family members affected with tuberculoid leprosy and the preferential segregation of HLA-DR2 into tuberculoid leprosy patients, an increased frequency of DR2 among the "sporadic" patients was expected. However, no heterogeneity for HLA was detected between patients and controls. These findings could indicate that tuberculoid leprosy is a heterogeneous disease with regard to genetic background.</p>  a0001-2815