01584nas a2200313   4500000000100000008004100001260000900042653001000051653003900061653001100100653001900111653001200130653001800142653001100160653001200171653000900183653001400192653001600206653001700222100001300239700001400252700001500266700001800281245005600299300001100355490000700366520088300373022001401256       1979                            d  c197910aAdult10aAfrican Continental Ancestry Group10aFemale10aGene Frequency10aGermany10aGlycoproteins10aHumans10aleprosy10aMale10aPhenotype10aPhilippines10aSouth Africa1 aWalter H1 aHilling M1 aBrachtel R1 aHitzeroth H W00aOn the population genetics of beta2-glycoprotein I.  a236-410 v293 a<p>Beta2-glycoprotein I typings on 152 healthy Germans and 150 patients with atopic diseases did not show any differences in the serum protein concentrations or in the phenotype and gene frequencies. Compared to these German samples, Philippinos (n = 88) as well as healthy Negroes from South Africa (n = 192) revealed statistically significant lower concentrations of this serum protein. They differ also from the Germans with regard to phenotype and gene frequencies. A most striking result was found in the comparison of healthy and leprous Negroes (n = 250) from South Africa. In these, quite different and statistically significant beta 2-Glycoprotein I concentrations, respectively, phenotype and gene frequencies were seen, which may be due to this disease. The possible reasons for these observations as well as for the observed population differences are discussed.</p>  a0001-5652