02366nas a2200457   4500000000100000008004100001260001300042653001500055653001000070653002100080653000900101653001600110653002500126653001000151653002500161653001100186653001100197653001400208653001000222653001200232653000900244653001600253653001500269653002800284653003100312653001700343653002100360653001600381100001500397700001500412700001900427700001700446700001700463245012900480856005900609300001100668490000700679050003200686520117600718022001401894       1999                            d  c1999 Sep10aAdolescent10aAdult10aAge Distribution10aAged10aBCG Vaccine10aCase-Control Studies10aChild10aConfidence Intervals10aFemale10aHumans10aIncidence10aIndia10aleprosy10aMale10aMiddle Aged10aOdds Ratio10aPopulation Surveillance10aReproducibility of Results10aRisk Factors10aSex Distribution10aVaccination1 aZodpey S P1 aBansod B S1 aShrikhande S N1 aMaldhure B R1 aKulkarni S W00aProtective effect of Bacillus Calmette Guerin (BCG) against leprosy: a population-based case-control study in Nagpur, India.  uhttp://leprev.ilsl.br/pdfs/1999/v70n3/pdf/v70n3a09.pdf  a287-940 v70  aInfolep Library - available3 a<p>A population-based pair-matched case-control study was carried out in an urban community, Nagpur, India, to estimate the effectiveness of BCG vaccination in the prevention of leprosy. The study included 212 cases of leprosy (diagnosed by WHO criteria), below the age of 35 years, detected during a leprosy survey conducted by the Government of Maharashtra over a population of 20,03,325. Each case was pair-matched with one neighbourhood control for age, sex and socioeconomic status. A significant protective association between BCG and leprosy was observed (OR = 0.40, 95% CI = 0.23-0.68). The overall vaccine effectiveness (VE) was estimated to be 60% (95% CI = 32-77). The BCG effectiveness against multi-bacillary and paucibacillary leprosy was 72% (95% CI = 35-88) and 45% (95% CI = 3-73), respectively. Vaccine was more effective during the first decade of life, among females and in lower socioeconomic strata. The overall prevented fraction was 39% (95% CI = 16-58). In conclusion, this first ever population-based case control study performed in Central India, identified a beneficial role of BCG vaccination in prevention of leprosy in study population.</p>  a0305-7518