01719nas a2200385   4500000000100000008004100001260001600042653002300058653003200081653001100113653002000124653003800144653002500182653001100207653001000218653001200228653000900240653002700249653002500276100001100301700001400312700001600326700001900342700001100361700001400372700001500386700001700401700001100418245009600429300001100525490000800536050001400544520076100558022001401319       2002                            d  c2002 Oct 1510aChromosome Mapping10aChromosomes, Human, Pair 2010aFemale10aGenetic Markers10aGenetic Predisposition to Disease10aGenetics, Population10aHumans10aIndia10aleprosy10aMale10aMicrosatellite Repeats10aMycobacterium leprae1 aTosh K1 aMeisner S1 aSiddiqui RM1 aBalakrishnan K1 aGhei S1 aGolding M1 aSengupta U1 aPitchappan R1 aHill A00aA region of chromosome 20 is linked to leprosy susceptibility in a South Indian population.  a1190-30 v186  aTOSH 20023 a<p>A major susceptibility locus for leprosy has recently been mapped on chromosome 10 (10p13) by genome-wide linkage analysis. Microsatellite markers from this genome screen that showed suggestive evidence of linkage to leprosy were evaluated in an additional 140 families with affected sib pairs. A second region of linkage has thus been identified on chromosome 20 (20p12). The peak of linkage lies at marker D20S115, which has a significant single-point maximum logarithm of odds score of 3.48 (P=.00003). Transmission disequilibrium testing of the microsatellite markers in 20p12 showed that the marker D20S835 is associated with protection against leprosy (P=.021), which suggests that a locus controlling susceptibility lies close to this marker.</p>  a0022-1899