01170nas a2200265   4500000000100000008004100001260001600042653001200058653002700070653001100097653001200108653000900120653002500129653001700154653001400171100001500185700001400200700001900214700001600233245006500249300001000314490000800324520055800332022001400890       1974                            d  c1974 Mar 0110aAnimals10aDisease Models, Animal10aHumans10aleprosy10aMice10aMycobacterium leprae10aTime Factors10aXenarthra1 aStorrs E E1 aWalsh G P1 aBurchfield H P1 aBinford C H00aLeprosy in the armadillo: new model for biomedical research.  a851-20 v1833 a<p>Eight of twenty armadillos (Dasypus novemcinctus L.) developed severe lepromatous leprosy 3 to 3.5 years after inoculation with viable Mycobacterium leprae. A total of 988 grams of lepromas containing an estimated 15 to 20 grams of leprosy bacilli has been harvested from these animals. The large amounts of material now available will permit in-depth studies of the biochemistry and metabolism of the leprosy bacillus, and the animal model should make possible definitive studies on the immunology, chemotherapy, and epidemiology of the disease.</p>  a0036-8075