01856nas a2200313   4500000000100000008004100001260000900042653002400051653001100075653001100086653001200097653001600109653001200125653002500137653003100162653001700193653000900210653001500219100001300234700001400247700001400261700001600275245008800291856008300379300001000462490000700472520104900479022001401528       1972                            d  c197210aAntigens, Bacterial10aBiopsy10aHumans10aleprosy10aMacrophages10aMethods10aMycobacterium leprae10aMycobacterium lepraemurium10aPhagocytosis10aSkin10aSkin Tests1 aConvit J1 aAvila J L1 aGoihman M1 aPinardi M E00aA test for the determination of competency in clearing bacilli in leprosy patients.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2480883/pdf/bullwho00193-0134.pdf  a821-60 v463 a<p>A skin test has been developed to determine the degree of competency in clearing bacilli from the tissues of patients suffering from various forms of leprosy. The test involves the intradermal injection of a suspension of killed Mycobacterium leprae. The response of leprosy patients to the injection of other mycobacterial antigens, one prepared from M. lepraemurium and another from an atypical mycobacterium from a hamster, was also investigated in order to study the isopathic phenomenon. Since lepromatous patients react negatively in tests with standard Mitsuda antigen, a concentration of 640 x 10(6)M. leprae per ml was used to produce macroscopic responses. The results of the test can be applied to determine the duration of consolidation treatment for lepromatous and indeterminate bacteriologically negative patients after regular treatment has ended. The test can also be used to indicate which Mitsuda-negative contacts should be given preventive treatment, and might be used to identify a given mycobacterium as M. leprae.</p>  a0042-9686