01567nas a2200361   4500000000100000008004100001260001700042653001500059653001000074653001200084653001500096653001200111653000900123653003700132653001800169653001100187653001100198653002400209653002000233653001200253653001200265653002600277653001600303653000900319100001700328700001400345245007500359856004100434300001100475490000700486520069800493022001401191       1974                            d  c1974 Oct-Dec10aAdolescent10aAdult10aAnimals10aBlastocyst10aDapsone10aDogs10aDose-Response Relationship, Drug10aEthnic Groups10aFemale10aHumans10aIn Vitro Techniques10aInfant, Newborn10aLectins10aleprosy10aLymphocyte Activation10aLymphocytes10aMale1 aBeiguelman B1 aPisam R C00aEffect of DDS on phytohemagglutinin-induced lymphocyte transformation.  uhttp://ila.ilsl.br/pdfs/v42n4a04.pdf  a412-150 v423 a<p>The influence of DDS on PHA-induced lymphocyte transformation was investigated in leukocyte cultures from two samples of healthy Caucasoid individuals. In one sample the sulfone-treated cultures differed from the controls in that they contained 0.4 mug/ml of other sample, the treated cultures contained DDS in concentrations of 4 mug/ml, 8 mug/ml and 16 mug/ml. The frequency of lymphocyte transformation induced by PHA was significantly reduced by DDS in all concentrations used. The data obtained are a strong indication that the plasma levels of dapsone among leprosy patients may contribute to the depression of the blastogenic capacity of their lymphocytes when stimulated by PHA.</p>  a0148-916X