01435nas a2200253   4500000000100000008004100001260001300042653001200055653001100067653001200078653000900090653001500099653000900114653002500123100001200148700001500160700001700175245005700192300001000249490000700259050003200266520086900298022001401167       1979                            d  c1979 Jan10aAnimals10aFemale10aleprosy10aMale10aMast Cells10aMice10aUrticaria Pigmentosa1 aKumar R1 aVaidya M C1 aKeshwani N H00aIn vivo response of mast cells to lepromatous serum.  a49-530 v51  aInfolep Library - available3 a<p>Adult healthly mice of pure line Institute strain were given, into the foot pad, an intradermal injection of normal human serum in group A and lepromatous serum in group B. In both groups, the animals were killed at varying time intervals. Serial paraffin sections of the foot pad skin 5--7 mu thick, were cut and stained with haematoxylin and eosin, toludine blue, acridine orange and para-bromaniline. On comparing the two groups, in group B the response of mast cells was more prompt, pronounced and persistant. The increase in the number of cells was accompanied by explosive degranulation around nerves, blood vessels and muscles. This response became less by 15 days but did not disappear completely. There were still few intact cells in the dermis. Histamine, heparin and 5-Ht showed a corresponding rise. The importance of the findings is discussed.</p>  a0024-1024