01578nas a2200301   4500000000100000008004100001260001300042653001500055653001000070653001000080653001200090653003100102653001100133653001200144653001500156653002300171653001500194100001600209700001400225700001100239700001200250700001600262245010600278300001100384490000700395520086000402022001401262       1979                            d  c1979 May10aAcedapsone10aAdult10aChild10aDapsone10aDrug Resistance, Microbial10aHumans10aleprosy10aMicronesia10aPatient Compliance10aRecurrence1 aRussell D A1 aWORTH R M1 aJano B1 aFasal P1 aShepard C C00aAcedapsone in the prevention of leprosy: field trial in three high prevalence villages in Micronesia.  a559-630 v283 a<p>The 1,659 non-leprous people in a Micronesian population experiencing an annual leprosy incidence rate of about 7/1,000 were offered 15 acedapsone (DADDS) injections during 1967--1970 for leprosy prevention purposes. Subsequent annual surveillance showed an initial cessation of new cases during the 3-year DADDS campaign, followed by a resumption of cases thereafter at a yearly level of about 2/1,000 with a longer pause and slower rise among those who received the full regimen. A secondary wave of cases that has occurred since 1973 among children born after 1968 shows that post-campaign transmission occurred, probably principally from relapsing multibacillary cases with onset before the campaign. Recommendations are made for a balanced, long-term control program with DADDS preventive treatment limited to contacts of multibacillary cases.</p>  a0002-9637