01311nas a2200289   4500000000100000008004100001260001600042653003200058653002100090653002800111653001100139653001200150653001600162653001800178653002500196653001300221653001700234100001400251700001200265700001200277700001700289245010800306300001000414490000600424520057700430022001401007       1968                            d  c1968 Oct 2610aAdrenocorticotropic Hormone10aErythema Nodosum10aHistological Techniques10aHumans10aleprosy10aLymph Nodes10aLymphadenitis10aMycobacterium leprae10aNecrosis10aPrednisolone1 aKarat A B1 aKarat S1 aJob C K1 aSudarsanam D00aAcute necrotizing lepromatous lymphadenitis: an erythema-nodosum-leprosum-like reaction in lymph nodes.  a223-40 v43 a<p>Histological examination of lymph-node biopsy specimens in 12 patients with erythema nodosum leprosum showed almost complete replacement of the node by lepromatous granuloma, together with considerable polymorph infiltration. Ziehl-Neelsen staining demonstrated numerous Mycobacterium leprae present in the nodes. The majority of these patients were very ill, and responded to prednisolone or corticotrophin.It is suggested that the histological appearances may represent an intensive inflammatory response in the lymph nodes followed by avascular aseptic necrosis.</p>  a0007-1447