01869nas a2200409   4500000000100000008004100001260001300042653001900055653001200074653002200086653002500108653001100133653003400144653001700178653002200195653001200217653001900229653003600248653000900284653002100293653002800314653001700342653001700359653002600376653001100402653001500413100001500428700001600443700001900459700001300478700001500491245006400506300000900570490000700579520085900586022001401445       1973                            d  c1973 Jan10aAdenocarcinoma10aAnimals10aAntibodies, Viral10aAntilymphocyte Serum10aHumans10aImmunity, Maternally-Acquired10aImmunization10aImmunosuppression10aleprosy10aLung Neoplasms10aMammary Neoplasms, Experimental10aMice10aMice, Inbred CBA10aNeoplasms, Experimental10aOsteosarcoma10aPolyomavirus10aSarcoma, Experimental10aSpleen10aThymectomy1 aGaugas J M1 aAllison A C1 aChesterman F C1 aRees R J1 aHirsch M S00aImmunological control of polyoma virus oncogenesis in mice.  a10-70 v273 a<p>Adult CBA mice thymectomized, treated with antilymphocytic globulin (ALG) and inoculated with human leprosy organisms were accidentally infected with polyoma virus and all developed tumours. After cessation of ALG administration, some animals were given spleen cells from syngeneic donors immunized with polyoma virus; none developed tumours. Similar results were obtained in mice deliberately infected with polyoma virus but not with leprosy organisms. Passive transfer of antibody before but not after virus inoculation prevented tumour formation in immunosuppressed recipients. Virus infection in thymectomized, lethally irradiated and bone marrow reconstituted mice resulted in only a very low incidence of tumours. These results emphasize the role of immunological surveillance in preventing polyoma tumour formation under natural conditions.</p>  a0007-0920