02310nas a2200337   4500000000100000008004100001260001300042653001000055653001800065653002500083653001600108653001100124653001700135653003000152653001100182653001000193653002500203653000900228653002600237653003000263653002800293100001700321700001400338700001500352245016200367856009000529300001100619490000700630520132100637022001401958       2000                            d  c2000 Jul10aAdult10aBase Sequence10aCase-Control Studies10aDNA Primers10aFemale10aHLA Antigens10aHSP70 Heat-Shock Proteins10aHumans10aIndia10aLeprosy, Tuberculoid10aMale10aPolymorphism, Genetic10aPromoter Regions, Genetic10aTuberculosis, Pulmonary1 aRajalingam R1 aMehra N K1 aSingal D P00aPolymorphism in heat-shock protein 70-1 (HSP70-1) gene promoter region and susceptibility to tuberculoid leprosy and pulmonary tuberculosis in Asian Indians.  uhttp://nopr.niscair.res.in/bitstream/123456789/24020/1/IJEB%2038%287%29%20658-662.pdf  a658-620 v383 a<p>Heat shock proteins (HSP) act as immunological target structures either by themselves because of an unusual expression pattern, or they are carrier proteins for immunogenic peptides. A three-allele polymorphism of HSP70-1 promoter region was analysed in random patients with pulmonary tuberculosis (PTB), or with tuberculoid (TT) leprosy and healthy controls from North India. HSP70-1A and HSP70-1C occurred more frequently (> 60%) while HSP70-1B occurred infrequently in this population. Only HSP70-1A allele was significantly increased in TT leprosy as compared to healthy controls (91.8% Vs 71.1%, Pc < 0.03, RR = 4.58). Although a strong association of HLA-DR15 was observed with both of these patient groups in earlier studies, no correlation was found between HSP70-1 promoter alleles with any of the HLA allotypes. Amongst six possible genotype combinations of HSP70-1 promoter allele, only four (A/A, A/B, A/C, C/C) were encountered in Asian Indians. A significant increase of HSP70-1 A/C genotype was observed among DR15 negative PTB patients as compared to DR15 negative controls (87.5% Vs 35.7%, X2 = 8.6, Pc < 0.02) giving highest relative risk of 12.6. These findings suggest that HSP70-1 genes may play a secondary role to HLA-DR in governing susceptibility to mycobacterial infectious diseases.</p>  a0019-5189