01711nas a2200421   4500000000100000008004100001260001700042653002100059653001800080653001200098653001900110653001100129653001700140653002100157653002300178653002300201653001100224653002900235653001700264653001200281653001100293653001400304653003300318653001600351653001800367653001800385653000900403653002600412100001500438700001800453700001700471245006800488856004100556300001100597490000700608520066000615022001401275       1974                            d  c1974 Oct-Dec10aAcid Phosphatase10aAcute disease10aAnimals10aArylsulfatases10aBiopsy10aChick Embryo10aErythema Nodosum10aGlycosaminoglycans10aHistocytochemistry10aHumans10aHyaluronoglucosaminidase10aInflammation10aleprosy10aLipids10aLysosomes10aMononuclear Phagocyte System10aNeutrophils10aPeriodic Acid10aPhospholipids10aSkin10aStaining and Labeling1 aAbalos R M1 aTolentino J G1 aBustillo C C00aHistochemical study of Erythema nodosum leprosum (ENL) lesions.  uhttp://ila.ilsl.br/pdfs/v42n4a01.pdf  a385-910 v423 a<p>A histochemical study of ENL lesions was performed on skin biopsies from 14 leproma-tous patients. There was: 1) the presence of moderate amounts of PAS positive diastase resistant materials, acid mucopolysaccharide, neutral fat, phospholipid, aryl sulfatase and acid phosphatase in areas around and away from reactional sites; 2) the presence of slight amounts or complete absence of these materials within areas of acute inflammation. These changes were interpreted as the result of solubilization and leakage of hydrolytic enzymes into the surrounding tissue. A possible role of lysosomal enzymes in the pathogenesis of ENL lesions is discussed.</p>  a0148-916X